Two Different Composite Markers Predict Severity and Threshold Dose in Peanut Allergy

Background Safe and cost-effective biological surrogate markers to evaluate the severity threshold dose of peanut allergy (PA) reactions during an oral food challenge (OFC) are lacking. Objective To associated with allergic reaction OFC in a population children PA. Methods Demographic parameters basophil activation test (BAT) results were collected. Patients stratified into 2 groups (mild-to-moderate severe) cumulative groups: low (LCTG) ≤100 mg crushed high >100 mg. Results Among 68 included, there was 96% concordance between BAT result for diagnosis Of 56 positive (median age: 8.8 years), not correlated (P = .24). Higher Ara h 2–specific IgE FcεRI-positive control values both severe peanut. Combining these led 92% sensitivity (84%-97%) 82% specificity (71%-89%) all subjects. For LCTG, 4-variable composite marker, including age, normalized (EC50), FcεRI- fMLP-positive values, resulted 97% (89%-99%) 61% (49%-71%). Conclusion Distinct allergen-specific non–allergen-specific appear be